The Liver Meeting 2019-ALF and Systemic Hyperinflammation: Phenotypic Similarities and Therapeutic Implications

ALF and Systemic Hyperinflammation: Phenotypic Similarities and Therapeutic Implications

Video Transcription

Video Summary

The transcript discusses the role of CD8 T cells in pediatric acute liver failure, specifically the indeterminate cases. The study found that these cases are marked by a massive CD8 T cell infiltration in the liver, suggesting an immune dysregulation component. The CD8 T cells identified in these cases were predominantly effector memory cells, expressing markers of tissue-resident memory and perforin, indicating an angry, activated state. Clonality analysis showed that these T cells are likely responding to a specific antigen. The study also explored the possibility of identifying these cells in peripheral blood for less invasive diagnostics. The findings suggest that these CD8 T cells play a pathogenic role and may be targetable with therapeutic interventions. More research is needed to identify the antigen driving the response and potential treatment targets.

Asset Caption

Presenter: Edward Behrens

Keywords

CD8 T cells

pediatric acute liver failure

immune dysregulation

effector memory cells

tissue-resident memory

perforin