SIG Greatest Hits: TLM 2025-Hepatotoxicity SIG: Wait! Wait! Don't DILI

Video Transcription

Video Summary

The video presents an engaging session from the Hepatotoxicity Special Interest Group (SIG) featuring prominent hepatologists and researchers discussing liver disease, drug-induced liver injury (DILI), and emerging hepatotoxicity research. Hosted by James Leindyke and Lily Dara, the event includes a "Celebrity Hepatologist Interview" with Jay Hufnagel, a distinguished expert in viral hepatitis and DILI. Jay reflects on his influential career, including seminal contributions to hepatitis B research and the establishment of networks for studying idiosyncratic DILI. The session incorporates interactive elements, such as quizzes and games inspired by NPR’s "Wait, Wait, Don’t Tell Me," creating a lively atmosphere.<br /><br />Further presentations highlight contemporary research findings. Paola Nicoletti discusses the role of human leukocyte antigen (HLA) genetics in predicting DILI risk, noting that while certain HLA alleles are associated with drug hypersensitivity, predictive power remains limited and future polygenic scoring may improve risk assessment. Jacob Bogdanoff explores immune checkpoint inhibitor-mediated liver injury (ILEC), employing advanced imaging mass cytometry to elucidate cellular interactions driving inflammation and liver damage, emphasizing the need for liver-specific therapies allowing continued cancer immunotherapy.<br /><br />Juliana Beyer addresses the impact of environmental hepatotoxicants, focusing on a vinyl chloride train derailment in East Palestine, Ohio. She underscores challenges in distinguishing environmental exposure effects from metabolic or genetic factors, advocating for improved clinical awareness, longitudinal studies, and integration of environmental health into hepatology. The session concludes with calls for collaboration between hepatologists and toxicologists to advance understanding and management of liver diseases influenced by drugs and environmental exposures. The event combines scientific rigor with interactive engagement, fostering community and inspiration among hepatotoxicity researchers.

Asset Subtitle

Join in the fun with the 3rd iteration of the popular (standing room only in 2024) and only (thank goodness) hepatotoxicity-themed game show at The Liver Meeting. The style and format of this workshop is loosely based on the NPR game show, "Wait wait...Don't Tell Me!". The Hepatotoxicity Special Interest Group has assembled a panel of experts to address cutting-edge topics in DILI and mechanisms of hepatotoxicity. Speakers present in a "speed data" format, with the majority of time left for discussion and engagement with panelists and the audience. Speakers are introduced by ridiculous limericks anchored in the topic of the presentation rather than extensive CVs.

Keywords

Hepatotoxicity

Liver Disease

Drug-Induced Liver Injury

DILI

Viral Hepatitis

Hepatitis B Research

Human Leukocyte Antigen

HLA Genetics

Immune Checkpoint Inhibitor

Liver Injury

Environmental Hepatotoxicants

Vinyl Chloride Exposure

Liver Toxicology