Hepatoxicity SIG (Sept 24): Long-term Experience of the Latin DILI Networking Focusing on NSAIDS-Long-term Experience of the Latin DILI Networking Focusing on NASAIDS

Video Transcription

Video Summary

In this presentation, Dr. Fernando Bessone, a noted gastroenterologist from the University of Rosario Medical School in Argentina, detailed his research on drug-induced liver injury (DILI) within the Latin DILI Network, highlighting the significant role of nonsteroidal anti-inflammatory drugs (NSAIDs). Dr. Bessone's extensive research, in collaboration with others, utilized data from over 400 patients spanning multiple countries, revealing the complexity and variability of DILI incidence among different populations.<br /><br />Key findings from his talk indicated that Amoxicillin-clavulanic acid remains the most frequent drug linked to DILI in Latin America, with herbal and dietary supplements (HDS) moving to second place. Despite Diclofenac and Ibuprofen being common over-the-counter drugs, their contribution to severe liver injury is considered low. Interestingly, the selective COX-2 inhibitors, such as Etoricoxib and Celecoxib, also demonstrated potential for severe liver damage despite their safer profiles compared to traditional NSAIDs.<br /><br />Dr. Bessone underscored the importance of genetic studies and biomarkers in understanding individual susceptibility to DILI, mentioning that existing definitions, such as Hy's Law, may not always predict outcomes accurately and could be drug-specific. Furthermore, the disparity in drug-induced liver injury incidences between regions like Latin America, the U.S., and Europe highlight the need for harmonized registries to accurately assess drug safety. <br /><br />Though NSAIDs are widely used globally, this comprehensive analysis underscores the challenges in monitoring and predicting adverse liver reactions, supporting a call for continued collaborative international research efforts and regulatory vigilance to ensure patient safety.

Keywords

Dr. Fernando Bessone

drug-induced liver injury

Latin DILI Network

NSAIDs

Amoxicillin-clavulanic acid

herbal and dietary supplements

genetic studies

biomarkers

Hy's Law

international research