Hepatoxicity SIG (Apr 24): Case-Based Discussion: 35-year-old male with Severe Liver Injury due to Turmeric Supplement-Case-Based Discussion_35 yo male with Severe Liver Injury due to Turmeric Supplement

Case-Based Discussion_35 yo male with Severe Liver Injury due to Turmeric Supplement

Video Transcription

Video Summary

In the seminar on drug-induced liver injury (DILI) by the American Association for the Study of Liver Diseases, experts discussed a case involving a 35-year-old male with hepatotoxicity linked to turmeric supplements. Presenters included Dr. Jim Luyendyk, Dr. David Kleiner, Dr. Iqbal Khan, and Dr. Dina Halegua-DiMarzio. The patient showed symptoms such as fatigue, itching, and jaundice after taking multiple supplements containing turmeric and piperine, a compound known to enhance the bioavailability of turmeric.<br /><br />The liver biopsy indicated cholestatic hepatitis with signs of liver injury and apoptosis. HLA genotyping identified the B3501 allele, potentially indicating a susceptibility to polyphenols in turmeric, paralleling findings in other cases associated with green tea and herbal drugs.<br /><br />Dr. Khan highlighted the inconsistency of supplement labeling, noting that many don't match their claimed ingredients, and discussed the potential for enhanced turmeric bioavailability due to piperine, which might increase the risk of liver injury.<br /><br />The session concluded with discussions on the complexity of idiosyncratic DILI, possible genetic predispositions, and the potential use of ursodiol in cholestatic injury, indicating an ongoing need for further research into herbal supplements and liver health.

Keywords

drug-induced liver injury

DILI

turmeric supplements

hepatotoxicity

cholestatic hepatitis

HLA genotyping

piperine

genetic predisposition

herbal supplements