Gut-liver Crosstalk Mediated by the Bile Acids-FXR-FGF15/19 Pathway-Gut-Live Crosstalk Mediated by the Bile Acids-FXR-FGF15/19 Pathway

Video Transcription

Video Summary

Dr. Grace Guo's presentation focused on the biological effects of bile acids, their role in activating cell signaling pathways, and their potential for cytotoxicity. She discussed the intricate process of bile acid synthesis, the species differences between humans and mice, and the role of specific receptors like FXR in regulating bile acid homeostasis. Dr. Guo highlighted the importance of understanding tissue-specific FXR functions to develop effective treatments for liver diseases, such as MASH and cholestasis. She emphasized the need for animal models that accurately represent human bile acid pathways, noting that current models, including mice, have limitations. Throughout her talk, Dr. Guo underscored the challenge of translating research findings into clinical applications due to these species differences and the complexity of the underlying biology. She also shared insights from her research on genetically modified mouse models and discussed potential adverse effects of FXR-targeted therapies. The presentation concluded with a reminder of the need for a deeper exploration of cell-specific bile acid signaling and FXR pathways to advance therapeutic strategies. The session ended with a Q&A, covering various topics from clinical implications of bile acid treatment to future research directions.

Keywords

bile acids

cell signaling

cytotoxicity

FXR receptors

liver diseases

animal models

species differences

therapeutic strategies

genetically modified mice