Fundamentals of Liver Disease - Abnormal Liver Tests 2.0-Module 6

Video Transcription

Video Summary

Cynthia Levy from the Division of Hepatology at the University of Miami discusses chronic cholestatic injury, its diagnosis, causes, and management. Chronic cholestasis involves impaired bile flow persisting for over six months, with elevated serum alkaline phosphatase being a key marker. Common causes include drug-induced liver injury, primary biliary cholangitis, and primary sclerosing cholangitis. Differentiating intra-hepatic and extra-hepatic cholestasis is crucial for diagnosis. Diagnostic steps involve history, physical exam, lab tests, and imaging. Treatment includes ursodeoxycholic acid for primary biliary cholangitis. Alarm signs like advanced fibrosis prompt specialist referral for monitoring, potential liver transplant candidacy, and cancer screening. Case studies illustrate the diagnostic process for patients with chronic cholestatic injury. Referral to a gastroenterologist is recommended for comprehensive management.

Keywords

chronic cholestatic injury

diagnosis

serum alkaline phosphatase

primary biliary cholangitis

Fundamentals of Liver Disease