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2024 Webinar: One ALT is not like the others
One ALT is not like the Other
One ALT is not like the Other
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Video Transcription
Video Summary
In this webinar, the speakers discussed the variability in ALT measurements due to different analyzers and assays, highlighting the need for standardization. They emphasized the importance of using lab reference ranges to interpret ALT levels accurately and cautioned against relying on fixed thresholds. The speakers also presented data from studies at Duke University and VA medical center that showed inconsistencies in ALT measurements across analyzers, further highlighting the need for harmonization. They addressed questions regarding low ALT levels, exclusion of potential liver pathologies in reference samples, and the implications of the FDA's final rule on laboratory-developed tests for standardizing ALT measurements. They concluded by highlighting the complexity of ALT measurement and the importance of collaboration between clinicians, laboratory professionals, and manufacturers to improve standardization and accuracy in ALT assessments.
Keywords
ALT measurements
variability
analyzers
assays
standardization
lab reference ranges
interpretation
data inconsistencies
harmonization
low ALT levels
Hepotoxicity
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