2024 Webinar: One ALT is not like the others-One ALT is not like the Other

Video Transcription

Video Summary

In this webinar, the speakers discussed the variability in ALT measurements due to different analyzers and assays, highlighting the need for standardization. They emphasized the importance of using lab reference ranges to interpret ALT levels accurately and cautioned against relying on fixed thresholds. The speakers also presented data from studies at Duke University and VA medical center that showed inconsistencies in ALT measurements across analyzers, further highlighting the need for harmonization. They addressed questions regarding low ALT levels, exclusion of potential liver pathologies in reference samples, and the implications of the FDA's final rule on laboratory-developed tests for standardizing ALT measurements. They concluded by highlighting the complexity of ALT measurement and the importance of collaboration between clinicians, laboratory professionals, and manufacturers to improve standardization and accuracy in ALT assessments.

Keywords

ALT measurements

variability

analyzers

assays

standardization

lab reference ranges

interpretation

data inconsistencies

harmonization

low ALT levels

Hepotoxicity