2023 Webinar: Understanding Mechanisms of MASLD Pathogenesis of Drug Development-Webinar Recording

Video Transcription

Video Summary

In this webinar, the speakers discussed various aspects of MASH-LD, including its pathogenesis, mechanisms of inflammation and fibrosis, and potential therapeutic targets. They highlighted the importance of understanding the role of immune cells and stellate cells in the development of MASH. Specifically, they discussed the role of B cells in inflammation and fibrosis, the role of lipid-associated macrophages in liver repair, and the potential for targeting senescent cells to improve liver function. The speakers also emphasized the heterogeneity of MASH and the need for personalized approaches to treatment. They discussed the challenges in developing effective therapies for MASH and fibrosis, and the importance of targeting specific aspects of inflammation and fibrosis. Overall, the speakers provided valuable insights into the current understanding of MASH-LD and future directions for research and therapy.

Keywords

MASH-LD

pathogenesis

mechanisms of inflammation

mechanisms of fibrosis

therapeutic targets

immune cells

stellate cells

B cells

lipid-associated macrophages

senescent cells