106: Liver Cancer Pathology-Liver Cancer Pathology (106)

Video Transcription

Video Summary

This webinar, moderated by Neeraja Kannan and Dr. Samara Elias, features Dr. Ilke Nalbantoglu discussing liver lesion pathology with a focus on liver cancer. Dr. Nalbantoglu explains how pathologists evaluate liver biopsies, differentiating benign from malignant lesions using liver architecture analysis and immunohistochemical staining techniques, including reticulin, CD34, glutamine synthetase, and glypican-3. She describes common benign hepatocellular lesions like focal nodular hyperplasia and hepatocellular adenomas in non-cirrhotic livers, emphasizing clinical context. The session covers nodules in cirrhotic livers, from regenerative to dysplastic nodules, and hepatocellular carcinoma (HCC), including its variants and prognostic markers. Combined hepatocellular-cholangiocarcinomas, their diagnosis, and implications are reviewed. Lastly, cholangiocarcinoma subtypes and their histological features are presented, noting distinct targetable mutations, especially in small-duct types. The webinar highlights the importance of integrated pathology, clinical data, and molecular profiling to improve liver cancer diagnosis and treatment.

Keywords

liver lesion pathology

liver cancer

immunohistochemical staining

hepatocellular carcinoma

cholangiocarcinoma

molecular profiling