PROMIS Computerized Adaptive Tests are Dynamic Instruments to Measure Health-Related Quality of Life in Cirrhosis
2011-11-04 - English - Quality of Life Issues

Cirrhotic pts have impaired quality of life(QOL).The PROMIS computerized adaptive tests(CAT)are freely available, non-copyrighted, QOL instruments with US-based norms across 11 domains(Table).Results are presented as %of US population that pts are better/worse off. CAT...(more)

Early decompensation and death rates in Veterans with Cirrhosis from 2000-2007: Alcoholic liver disease worsens the prognosis
2011-11-04 - English - Alcohol: Clinical and Experimental

Cirrhosis disproportionately affects the US Veteran Affairs (VA) population. Alcoholic liver disease (ALD) pts often delay seeking medical care which may affect their survival. Aim: to evaluate the effect of ALD on early (within 1 yr of cohort entry) decompensation &...(more)

The Stability of Minimal Hepatic Encephalopathy Diagnosis is Significantly Improved with the Addition of the Inhibitory Control test to a Standard Psychometric Battery
2011-11-04 - English - Ascites and Other Complications

Minimal hepatic encephalopathy (MHE) can be diagnosed using standard psychometric(SPT) or inhibitory control tests(ICT).However, the rate of MHE development & relative stability of this diagnosis over time is not clear.This is important to counsel pts and to design MHE...(more)

Hepatic Encephalopathy after TIPS: Role of Specialized Brain MR imaging and Cognitive Testing
2011-11-04 - English - Ascites and Other Complications

Hepatic encephalopathy(HE)development post-TIPS can be difficult to predict.Along with cognitive dysfunction, HE pts have higher glutamine/glutamate(Glx) & lower myoinositol(mI)on brain MR Spectroscopy(MRS) with brain edema on diffusion tensor imaging (DTI). However, the...(more)

Linkage of gut microbiome with cognition and inflammation in hepatic encephalopathy
2011-11-04 - English - Ascites and Other Complications

Hepatic encephalopathy(HE) is related to gut bacteria and inflammation with intestinal barrier dysfunction. Aim:To link the gut microbiome with cognition and inflammation in cirrhotics with/without HE using a systems biology approach. Methods:Cirrhotic pts...(more)

In hospital Mortality in Cirrhosis is Related to Infections Independent of MELD score: A Prospective Multi-Center Study from the North American Consortium for the Study of End-Stage Liver Disease (NACSELD)
2011-11-04 - English - Ascites and Other Complications

Infections are associated with a poor prognosis in cirrhosis but the predictors of inpatient mortality are unclear. A prospective multi-center study of inpatients with infections is required. Aim: To prospectively define in a multi-center study factors that predict...(more)

Minimal Hepatic Encephalopathy: Investigate and Treat? (Pro)
2011-11-04 - English - Ascites and Other Complications

In hospital Mortality in Cirrhosis is Related to Infections Independent of MELD score: A Prospective Multi-Center Study from the North American Consortium for the Study of End-Stage Liver Disease (NACSELD)
2011-11-04 - English - Portal Hypertension and Other Complications of Cirrhosis

Rifaximin Improves Brain Edema and Working Memory in Minimal Hepatic Encephalopathy: A Prospective fMRI Study
2012-11-12 - English - Portal Hypertension and Other Complications of Cirrhosis

Minimal hepatic encephalopathy(MHE) pts have abnormal cognition, brain activation and cytotoxic brain edema on functional MR(fMR). However the effect of MHE Rx on fMR is not clear. Aim: evaluate effect of rifaximin on cognition, brain edema with diffusion tensor...(more)

Long-term use of rifaximin is associated with reduced hospitalizations, prolonged remission: a placebo crossover analysis
2012-11-12 - English - Portal Hypertension and Other Complications of Cirrhosis

Introduction: In a multinational double-blind (DB) trial (RFHE3001), rifaximin (RFX), a gut-targeted antibiotic that also exhibits bacterial and host endothelial modulating effects, reduced the risk of breakthrough overt hepatic encephalopathy (HE) (primary endpoint) vs....(more)

The Functional Basis of Improvement in Inhibitory Control in Minimal Hepatic Encephalopathy with Rifaximin Therapy
2012-11-12 - English - Portal Hypertension and Other Complications of Cirrhosis

Minimal hepatic encephalopathy(MHE) pts have difficulties with inhibitory control and attention, that is associated with driving difficulty and poor QOL. Inhibitory control test (ICT) evaluates response inhibition & has been used to diagnose MHE and predict outcomes. ICT...(more)

Minimal Hepatic Encephalopathy, 'Covert HE'
2012-11-11 - English - Other

Multiple organ dysfunction defines Acute-on-Chronic Liver Failure : the NACSELD study
2012-09-12 - English - Acute Liver Failure and Artificial Liver Support