IL-22 Gene Haplotype Polymorphisms Are Associated with the Risk of Liver Cirrhosis in Patients with Hepatitis B Virus
AASLD LiverLearning®. Gao Y. Nov 14, 2016; 144702
Topic: Immunopathogenesis
Yanhang Gao
Yanhang Gao
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TITLE: IL-22 Gene Haplotype Polymorphisms Are Associated with the Risk of Liver Cirrhosis in Patients with Hepatitis B Virus

National Natural Science Foundation of China

Backround and Aims: Chronic hepatitis B virus (HBV) infection affects over 300 million people worldwide and is a leading cause of cirrhosis in China. Many factors contribute to cirrhosis through direct and indirect mechanisms, but the exact pathogenesis is still not completely understood. Interleukin-22(IL-22) is a newly discovered cytokine secreted mainly by lymphocytes since 2000. Many studies have identified that IL-22 play an important role in most acute inflammatory diseases including acute liver injury. Meanwhile, there are also some researches reported that IL-22 may play a pathological role in some certain pathophysiological stages such as chronic inflammation. The effects and mechanisms of IL-22 in chronic HBV-related liver cirrhosis remain unclear. Method: In the present study, we investigated the association between IL-22 gene SNPs polymorphisms and the risks of HBV-related chronic liver diseases (including chronic hepatitis,CHB; liver cirrhosis,LC;hepatocellular carcinoma,HCC) among Han populations in China. A total of 649 subjects were included, including 103 cases with CHB, 264 cases with LC and 282 cases with HCC. Results: Distribution frequencies of genotypes and alleles on eight IL-22 single SNPs among CHB vs LC groups, LC vs HCC groups and CHB vs HCC groups were not observed the significant difference. Furthermore, haplotypes were analyzed in the above-mentioned groups. Compared between CHB and LC groups, the distributon of haplotype rs2227491&rs2227473 demonstrated the strongest association (P=0.006), and the corresponding haplotype genotypes (including A-A wild-type; A-G mutant; C-G mutant) distribution showed significant difference when A-G was compared with A-A (OR=0.598, 95%CI:0.413-0.865; P=0.006). Compared between LC and HCC groups, the distribution of haplotype rs2046068&rs2227491&rs2227473&rs7314777 showed the stongest association (P=0.024), and the corresponding haplotype genotypes (including G-A-A-C wild-type; G-C-G-T mutant; T-A-G-T mutant) distribution indicated significant difference when T-A-G-T was compared with G-A-A-C (OR=1.379, 95%CI:1.043-1.823; P=0.024). Compared between CHB and HCC groups, no any statistical difference was found on all the related haplotypes distribution. Conclusion: IL-22 single gene loci polymorphisms might not be associated with HBV-related liver disease among Han populations in China. IL-22 gene haplotype polymorphisms revealed the significant correlation with the development of liver cirrhosis in patients with HBV infection. A-A and G-A-A-C of IL-22 haplotype genotypes might be the risk factors for HBV-related cirrhosis development.
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